Oscillations in a Maturation Model of Blood Cell Production

DOI10.1137/050648055MaRDI QIDQ3427802zbMATH OpenOpenAlexFDO

Authors Ivana Drobnjak, M. C. Mackey, A. C. Fowler

Publication date 27 March 2007

Published in SIAM Journal on Applied Mathematics (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/q-bio/0409003

zbMATH Keywords

blood cell productionchronic myelogenous leukemiacyclical neutropeniadelay equationmathematical modelmaturation

Mathematics Subject Classification ID

Physiological flows (76Z05) Physiological flow (92C35)

Abstract: In this paper we use a continuous model to describe the development of a single cell lineage following the committal of stem cells. Three separate controls are implemented in the model, namely the proliferative control of stem cells, the proliferative control of developing blast cells, and the peripheral control of stem cell committal by circulating blood cell density. We show that variation of parameters in all three control systems can cause oscillations, and that the characters of these oscillations are very different. This allows us some potential insight into the mechanisms that may be operative in some of the dynamic blood diseases like cyclical neutropenia and periodic chronic myelogenous leukemia.

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Cited in

(14)

• Analysis of a system describing proliferative-quiescent cell dynamics
• Large fluctuations in multi-scale modeling for rest hematopoiesis
• Oscillations in cyclical neutropenia: new evidence based on mathematical modeling
• Oscillations in a white blood cell production model with multiple differentiation stages
• A mathematical model of multistage hematopoietic cell lineages
• Human haematopoiesis in steady state and following intense perturbations
• Control of oscillations in hematopoiesis
• ODE, RDE and SDE models of cell cycle dynamics and clustering in yeast
• A model of oscillatory blood cell counts in chronic myelogenous leukaemia
• Time delay in physiological systems: analyzing and modeling its impact
• Blood cell dynamics: half of a century of modelling
• Bifurcation and Bistability in a Model of Hematopoietic Regulation
• A Continuous Integral Model for White Blood Cell Production
• High frequency spikes in long period blood cell oscillations

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