Outlier detection in Mendelian randomization

DOI10.1002/SIM.70143MaRDI QIDQ6905027zbMATH OpenFDO

Authors Maximilian M. Mandl, Anne-Laure Boulesteix, Stephen Burgess, Verena Zuber

Publication date 6 November 2025

Published in Statistics in Medicine (Search for Journal in Brave)

Copyright license Creative Commons Attribution 4.0 International

Full work available at URL https://doi.org/10.1002/SIM.70143

zbMATH Keywords

instrumental variablesinvalid instrumentsMendelian randomizationoutlier detectionpleiotropy

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10)

Cites work

• Against the ``one method fits all data sets philosophy for comparison studies in methodological research
• Combining information on multiple instrumental variables in Mendelian randomization: comparison of allele score and summarized data methods
• Detecting pleiotropy in Mendelian randomisation studies with summary data and a continuous outcome
• Genomic Control for Association Studies
• Genomic control, a new approach to genetic-based association studies.
• Mendelian randomization. Methods for using genetic variants in causal estimation
• Phases of methodological research in biostatistics -- building the evidence base for new methods
• Statistical inference in two-sample summary-data Mendelian randomization using robust adjusted profile score
• Two-Stage Least Squares Estimation of Average Causal Effects in Models with Variable Treatment Intensity

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