pcsstools
CRANpcsstoolsMaRDI QIDQ128581FDOQ128581
Tools for Regression Using Pre-Computed Summary Statistics
Jack M. Wolf, R Core Team and Contributors Worldwide
Last update: 6 September 2023
Copyright license: GNU General Public License
Software version identifier: 0.1.1, 0.1.2
Defines functions to describe regression models using only pre-computed summary statistics (i.e. means, variances, and covariances) in place of individual participant data. Possible models include linear models for linear combinations, products, and logical combinations of phenotypes. Implements methods presented in Wolf et al. (2021) <doi:10.3389/fgene.2021.745901> Wolf et al. (2020) <doi:10.1142/9789811215636_0063> and Gasdaska et al. (2019) <doi:10.1142/9789813279827_0036>.
- Computationally efficient, exact, covariate-adjusted genetic principal component analysis by leveraging individual marker summary statistics from large biobanks
- Leveraging summary statistics to make inferences about complex phenotypes in large biobanks
- Using Summary Statistics to Model Multiplicative Combinations of Initially Analyzed Phenotypes With a Flexible Choice of Covariates
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