Penalized integrative analysis under the accelerated failure time model

DOI10.5705/SS.2014.194MaRDI QIDQ2796865zbMATH OpenOpenAlexFDO

Authors Sanguo Zhang, Jin Liu, Shuangge Ma, Qingzhao Zhang, Jian Huang

Publication date 30 March 2016

Published in Statistica Sinica (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1501.02458

zbMATH Keywords

consistency propertieshomogeneity and heterogeneity modelsintegrative analysispenalized selection

Mathematics Subject Classification ID

Linear regression; mixed models (62J05) Ridge regression; shrinkage estimators (Lasso) (62J07) Censored data models (62N01) Reliability and life testing (62N05) Applications of statistics to biology and medical sciences; meta analysis (62P10)

Abstract: For survival data with high-dimensional covariates, results generated in the analysis of a single dataset are often unsatisfactory because of the small sample size. Integrative analysis pools raw data from multiple independent studies with comparable designs, effectively increases sample size, and has better performance than meta-analysis and single-dataset analysis. In this study, we conduct integrative analysis of survival data under the accelerated failure time (AFT) model. The sparsity structures of multiple datasets are described using the homogeneity and heterogeneity models. For variable selection under the homogeneity model, we adopt group penalization approaches. For variable selection under the heterogeneity model, we use composite penalization and sparse group penalization approaches. As a major advancement from the existing studies, the asymptotic selection and estimation properties are rigorously established. Simulation study is conducted to compare different penalization methods and against alternatives. We also analyze four lung cancer prognosis datasets with gene expression measurements.

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(17)

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• Integrative analysis of multiple types of genomic data using an accelerated failure time frailty model
• Integrative survival analysis with uncertain event times in application to a suicide risk study
• Adaptive penalized weighted least absolute deviations estimation for the accelerated failure time model
• Promoting variable effect consistency in mixture cure model for credit scoring
• Integrative analysis of prognosis data on multiple cancer subtypes
• Identification of homogeneous and heterogeneous variables in pooled cohort studies
• Bayesian integrative analysis for multi-fidelity computer experiments
• Integrative analysis of cancer diagnosis studies with composite penalization
• Dimension Reduction for Integrative Survival Analysis
• Privacy-preserving and homogeneity-pursuit integrative analysis for high-dimensional censored data
• Integrative rank-based regression for multi-source high-dimensional data with multi-type responses
• Integrative analysis of high-dimensional quantile regression with contrasted penalization
• Integrative factor-adjusted sparse generalized linear models
• A Simple Divide-and-Conquer-based Distributed Method for the Accelerated Failure Time Model
• Multivariate regression modeling in integrative analysis via sparse regularization
• Promote sign consistency in the joint estimation of precision matrices

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