Performance Measures in Dose‐Finding Experiments

DOI10.1111/INSR.12363MaRDI QIDQ6085864zbMATH OpenOpenAlexFDO

Authors Nancy Flournoy, José A. Moler, Fernando Plo

Publication date 12 December 2023

Published in International Statistical Review (Search for Journal in Brave)

Copyright license Creative Commons Attribution 4.0 International

Full work available at URL https://doi.org/10.1111/insr.12363

zbMATH Keywords

adaptive designsmaximum tolerated doseoptimal designsperformance criteria

Mathematics Subject Classification ID

Point estimation (62F10) Optimal statistical designs (62K05) Applications of statistics to biology and medical sciences; meta analysis (62P10)

Recommendations

• Dose finding using the biased coin up-and-down design and isotonic regression
• Dose Finding for Continuous and Ordinal Outcomes with a Monotone Objective Function: A Unified Approach
• Dose Finding – A Challenge in Statistics
• Design efficiency in dose finding studies

Cites work

• Adaptive clinical trial designs for phase I cancer studies
• Bias reduction of maximum likelihood estimates
• Consistency of continual reassessment method under model misspecification
• Continual Reassessment Method: A Practical Design for Phase 1 Clinical Trials in Cancer
• Cumulative cohort design for dose-finding
• Design and Analysis of Phase I Clinical Trials
• Dose finding in drug development.
• Dose finding using the biased coin up-and-down design and isotonic regression
• scientific article; zbMATH DE number 3746271 (Why is no real title available?)
• scientific article; zbMATH DE number 193111 (Why is no real title available?)
• scientific article; zbMATH DE number 410131 (Why is no real title available?)
• scientific article; zbMATH DE number 3322699 (Why is no real title available?)
• Nonlinear sequential designs for logistic item response theory models with applications to computerized adaptive tests
• Operating characteristics of the standard phase I clinical trial design.
• Optimal Bayesian-feasible dose escalation for cancer phase I trials
• Optimal design for nonlinear response models
• Optimal Designs for Dose–Response Models With Restricted Design Spaces
• Statistical Methods for Dose‐Finding Experiments
• The treatment versus experimentation dilemma in dose finding studies

Cited in

(9)

• Coherence principles in dose-finding studies
• Efficiency of bridging between related dose finding studies
• Effect size measures and their benchmark values for quantifying benefit or risk of medicinal products
• scientific article; zbMATH DE number 5234396 (Why is no real title available?)
• On the maximum likelihood estimator of the Emax model
• Maximum likelihood estimation under the Emax model: existence, geometry and efficiency
• Influence of the slope in percentile estimation through binary regression for dose-finding experiments
• Dose-Finding Based on Efficacy-Toxicity Trade-Offs
• A semi-Markov process for the K-in-a-Row design

This page was built for publication: Performance Measures in Dose‐Finding Experiments

Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q6085864)