phase1RMD

MaRDI QIDQ7388295CRANFDO

Authors Jun Yin, Yu Du, Sumithra Mandrekar

Last update 11 March 2020

Copyright license GNU General Public License, version 2.0, GNU General Public License, version 3.0

Software version identifier PACKAGES.rds, 1.0.5, 1.0.7, 1.0.8, 1.0.9

Description

Implements our Bayesian phase I repeated measurement design that accounts for multidimensional toxicity endpoints from multiple treatment cycles. The package also provides a novel design to account for both multidimensional toxicity endpoints and early-stage efficacy endpoints in the phase I design. For both designs, functions are provided to recommend the next dosage selection based on the data collected in the available patient cohorts and to simulate trial characteristics given design parameters. Yin, Jun, et al. (2017) <doi:10.1002/sim.7134>.

Cites work

• A Bayesian dose-finding design incorporating toxicity data from multiple treatment cycles

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