Phase II trial design with Bayesian adaptive randomization and predictive probability

DOI10.1111/J.1467-9876.2011.01006.XMaRDI QIDQ6637640zbMATH OpenFDO

Authors Guosheng Yin, Nan Chen

Publication date 13 November 2024

Published in Journal of the Royal Statistical Society. Series C. Applied Statistics (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1111/J.1467-9876.2011.01006.X

zbMATH Keywords

adaptive randomizationBayesian inferenceclinical trial ethicsgroup sequential methodposterior predictive distributionrandomized trialtype I errortype II error

Mathematics Subject Classification ID

Applications of statistics (62Pxx)

Cited in

(5)

• BILITE: a Bayesian randomized phase II design for immunotherapy by jointly modeling the longitudinal immune response and time-to-event efficacy
• Optimal Bayesian predictive probability for delayed response in single-arm clinical trials with binary efficacy outcome
• A Bayesian adaptive phase III design for multi-arm trials with time-to-event endpoint for nonproportional hazards utilizing the generalized gamma distribution
• A randomized two-stage design for phase II clinical trials based on a Bayesian predictive approach
• Group response-adaptive randomization with delayed and missing responses

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