Counting Process Based Dimension Reduction Methods for Censored Outcomes

DOI10.48550/ARXIV.1704.05046zbMATH Open1506.62386arXiv1704.05046OpenAlexW2609495673WikidataQ91871300 ScholiaQ91871300MaRDI QIDQ101643FDOQ101643

Donglin Zeng, Qiang Sun, Tao Wang, Ruoqing Zhu, Donglin Zeng, Ruoqing Zhu, Qiang Sun, Tao Wang

Publication date: 17 April 2017

Published in: Biometrika (Search for Journal in Brave)

Abstract: We propose a class of dimension reduction methods for right censored survival data using a counting process representation of the failure process. Semiparametric estimating equations are constructed to estimate the dimension reduction subspace for the failure time model. The proposed method addresses two fundamental limitations of existing approaches. First, using the counting process formulation, it does not require any estimation of the censoring distribution to compensate the bias in estimating the dimension reduction subspace. Second, the nonparametric part in the estimating equations is adaptive to the structural dimension, hence the approach circumvents the curse of dimensionality. Asymptotic normality is established for the obtained estimators. We further propose a computationally efficient approach that simplifies the estimation equation formulations and requires only a singular value decomposition to estimate the dimension reduction subspace. Numerical studies suggest that our new approaches exhibit significantly improved performance for estimating the true dimension reduction subspace. We further conduct a real data analysis on a skin cutaneous melanoma dataset from The Cancer Genome Atlas. The proposed method is implemented in the R package "orthoDr".

Full work available at URL: https://arxiv.org/abs/1704.05046

zbMATH Keywords

estimating equationsliced inverse regressionsurvival analysissemiparametric inferencesufficient dimension reduction

Mathematics Subject Classification ID

Asymptotic properties of parametric estimators (62F12) Nonparametric estimation (62G05) Nonparametric regression and quantile regression (62G08) Censored data models (62N01) Estimation in survival analysis and censored data (62N02) Applications of statistics to biology and medical sciences; meta analysis (62P10) Asymptotic distribution theory in statistics (62E20)

Cited In (6)

• Double-slicing assisted sufficient dimension reduction for high-dimensional censored data
• A new reproducing kernel‐based nonlinear dimension reduction method for survival data
• Counting process approach to time sequential and sequential point estimation with censored data
• orthoDr
• Penalized generalized empirical likelihood with a diverging number of general estimating equations for censored data
• Support vector hazards machine: a counting process framework for learning risk scores for censored outcomes

Uses Software

• R
• Rcpp
• dr

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