Towards an optimal drug-delivery regimen for methotrexate chemotherapy

DOI10.1016/0096-3003(83)90002-4zbMath0517.92005MaRDI QIDQ1053635

J. Blot

Publication date: 1983

Published in: Applied Mathematics and Computation (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1016/0096-3003(83)90002-4

zbMATH Keywords

compartment model; cancer chemotherapy; maximum tumor-cell damage; methotrexate chemotherapy; minimum normal-cell damage; optimal drug-delivery regimen

Mathematics Subject Classification ID

93C05: Linear systems in control theory

92C50: Medical applications (general)

80A30: Chemical kinetics in thermodynamics and heat transfer

93C15: Control/observation systems governed by ordinary differential equations

92Cxx: Physiological, cellular and medical topics