Extension of the theory of the multiple-indicator dilution technique to metabolic systems with an arbitrary number of rate constants

DOI10.1016/0025-5564(84)90005-1MaRDI QIDQ1059564zbMATH OpenOpenAlexFDO

Authors Andreas J. Schwab

Publication date 1984

Published in Mathematical Biosciences (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1016/0025-5564(84)90005-1

zbMATH Keywords

arbitrary number of metabolic rate constantscollection of capillariescompartmental analysishepatic lactate metabolismimpulse responseLaplace transformslivermultiple- indicator dilution techniquespace-distributed modificationuniform large-vessel transit timesvariable capillary

Mathematics Subject Classification ID

Transform methods (e.g., integral transforms) applied to PDEs (35A22) Physiological flows (76Z05) Medical applications (general) (92C50) Physiological, cellular and medical topics (92Cxx)

Review text

Results of experiments performed following the so called multiple- indicator dilution technique have been evaluated by a space-distributed modification of the classical compartmental analysis. The evaluations are applied in the case of hepatic lactate metabolism. An organ (i.e. the liver) is considered as a collection of capillaries. Firstly, basic equations of the motion of perfusate in a single capillary are derived and subsequently an evaluation of the impulse response of a whole organ is carried out. In the reviewer's opinion, some parts of this work could be given a more exact and clear formulation.

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Cites work

• A comparative study of organ models and numerical techniques for the evaluation of capillary permeability from multiple-indicator data
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• An Algorithm for Least-Squares Estimation of Nonlinear Parameters
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• scientific article; zbMATH DE number 194949 (Why is no real title available?)
• scientific article; zbMATH DE number 3408799 (Why is no real title available?)
• Matrix eigensystem routines - EISPACK guide
• Numerical Inversion of Laplace Transforms Using a Fourier Series Approximation
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• THEOREMS ON LINEAR SYSTEMS*

Cited in

(7)

• Complete monotonicity of flow and cross-sectional impulse response functions for rigid right circular tubes
• On indicator dilution and perfusion heterogeneity: A stochastic model
• Moment relations in indicator dilution theory
• An isotope dilution model for partitioning of phenylalanine and tyrosine uptake by the liver of lactating dairy cows
• Analogue tracers and lumped constant in capillary beds
• Extending the multiple indicator dilution method to include slow intracellular diffusion
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Describes a project that uses

Uses Software

• CADRE
• EISPACK

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