A model of electrophoretic variation: Finite populations and finite numbers of mutable sites

DOI10.1016/0040-5809(80)90036-2MaRDI QIDQ1064282zbMATH OpenOpenAlexWikidataFDO

Authors C. F. Wehrhahn, Charles Lloyd Gulizia

Publication date 1980

Published in Theoretical Population Biology (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1016/0040-5809(80)90036-2

zbMATH Keywords

amino acid sitesexpected variance in chargefinite numbers of mutable sitesfinite populationsgene conversioninfinite mutable sites modelintragenic recombinationmodel of electrophoretic variationneutral genetic variationprotein

Mathematics Subject Classification ID

Physiological, cellular and medical topics (92Cxx) Genetics and epigenetics (92D10)

Review text

In this paper we present a model of electrophoretic variation for a protein with M amino acid positions, each of which can be in the selectively equivalent charge states 0 and 1. At each amino acid position the mutation rate from one charge state to the other is \(\nu\). We derive the expected variance in charge, for a population of N individuals in generation t, which is \(\sigma^ 2(t)=[2MN\nu /(1+8N\nu)]\{1-\exp [- (4\nu +1/(2N))t]\}\) for an initially monomorphic population. This variance, which is unaffected by intragenic recombination and gene conversion, does not increase linearly with N as does the steady-state variance in charge for the older electrophoretic models. We also derive the probability, \(P_ j(t)\), that a random gene in a population exceeds another by j charge units. We conclude: (1) that, except for species which have maintained effective population numbers in the millions, the infinite mutable sites model adequately describes neutral genetic variation; (2) that very high levels of 'neutral' genetic variation can be attained only by genes with a fairly large number of 'neutral' amino acid sites in species which have maintained an effective size in the millions for millions of generations; (3) that, because all species surveyed have a mean heterozygosity of less than 25\%, it is likely that most genes have only a few 'neutral' covarions.

Recommendations

• A genetic model with mutation and selection
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Cites work

• Ehrenfest urn models
• scientific article; zbMATH DE number 3126031 (Why is no real title available?)
• scientific article; zbMATH DE number 3588427 (Why is no real title available?)
• scientific article; zbMATH DE number 3220189 (Why is no real title available?)
• scientific article; zbMATH DE number 3390587 (Why is no real title available?)
• Model of effectively neutral mutations in which selective constraint is incorporated
• The sampling theory of selectively neutral alleles
• Wandering distributions and the electrophoretic profile

Cited in

(3)

• scientific article; zbMATH DE number 3896721 (Why is no real title available?)
• Statistical Analysis of Data from Gene Frequency Perturbation Experiments
• The index of dispersion of molecular evolution: Slow fluctuations

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