The effect of cellular differentiation on the development of permanent drug resistance

DOI10.1016/0025-5564(85)90054-9zbMath0576.92009OpenAlexW2022562134MaRDI QIDQ1064978

Vincent Ng, James H. Goldie, Andrew J. Coldman

Publication date: 1985

Published in: Mathematical Biosciences (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1016/0025-5564(85)90054-9

zbMATH Keywords

growthcompartment modelKolmogorov equationscell differentiationmutationextinction probabilitiesexpected valuesBirth and death processesdevelopment of permanent drug resistancedoubly resistant cellsof human tumorssingle drug resistancespontaneous drug resistance of tumor stem cells

Mathematics Subject Classification ID

Applications of branching processes (60J85) Medical applications (general) (92C50) Population dynamics (general) (92D25)

Related Items (13)

The transient solution of the linear birth-death process with random spontaneous mutation ⋮ Time-dependent subpopulation induction in heterogeneous tumors ⋮ Models for dose intensity ⋮ Modeling growth of a heterogeneous tumor ⋮ Role of optimal control theory in cancer chemotherapy ⋮ A survey of optimization models on cancer chemotherapy treatment planning ⋮ Optimal control of tumor size used to maximize survival time when cells are resistant to chemotherapy ⋮ Low-intensity combination chemotherapy maximizes host survival time for tumors containing drug-resistant cells ⋮ A mathematical model of the P-glycoprotein pump as a mediator of multidrug resistance ⋮ Cancer chemotherapy with immunostimulation: A nonhomogeneous stochastic model for drug resistance. I: One drug case ⋮ A stochastic model for the origin and treatment of tumors containing drug-resistant cells ⋮ Stochastic models for subpopulation emergence in heterogeneous tumors ⋮ A mathematical model for the inhibition of the multidrug resistance- associated \(p\)-glycoprotein pump

Cites Work

• On the distribution of the number of mutants at the hypoxanthine-quanine phosphoribosal transferase locus in Chinese hamster ovary cells
• A model for the resistance of tumor cells to cancer chemotherapeutic agents
• Partial differential equations. 4th ed
• A STOCHASTIC MODEL OF STEM CELL PROLIFERATION, BASED ON THE GROWTH OF SPLEEN COLONY-FORMING CELLS

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