Approximate Michaelis-Menten kinetics displayed in a stochastic model of cell-mediated cytotoxicity

DOI10.1016/0025-5564(86)90046-5zbMath0598.92009OpenAlexW2005776890MaRDI QIDQ1080382

Stephen J. Merrill, Sivapragasa Sathananthan

Publication date: 1986

Published in: Mathematical Biosciences (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1016/0025-5564(86)90046-5

zbMATH Keywords

biochemistrylysiscomparison theorem for the pseudo-steady- state distributionenzyme-substrate kineticsMichaelis- Menten saturation functionnonlinear continuous-time Markov chainnonlinear regression procedurerelease of labelstochastic model of cell-mediated cytotoxicitytwo-step process of cytolytic cells binding

Mathematics Subject Classification ID

Applications of Markov chains and discrete-time Markov processes on general state spaces (social mobility, learning theory, industrial processes, etc.) (60J20) Chemical kinetics in thermodynamics and heat transfer (80A30) Continuous-time Markov processes on discrete state spaces (60J27) Physiological, cellular and medical topics (92Cxx)

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Cites Work

• A pseudo-steady state approximation for stochastic chemical kinetics
• Foundations of the use of an enzyme-kinetic analogy in cell-mediated cytotoxicity

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