Analysis of three- and four-compartment models for in vivo radioligand- neuroreceptor interaction

MaRDI QIDQ1091968zbMATH OpenFDO

Authors Barry R. Zeeberg, Henry N. jun. Wagner

Publication date 1987

Published in Bulletin of Mathematical Biology (Search for Journal in Brave)

zbMATH Keywords

PETkinetic datapositron emission tomographyfour-compartment modelmacroscopic rate constantsmicroscopic rate constantsradioligand-neuroreceptor interactionsthree-compartment models

Mathematics Subject Classification ID

Medical applications (general) (92C50) Probabilistic models, generic numerical methods in probability and statistics (65C20) Control/observation systems governed by ordinary differential equations (93C15) Physiological, cellular and medical topics (92Cxx)

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(5)

• Theoretical effects of radioligand diffusional gradients and microscopic neuroreceptor distribution in in vivo kinetic studies
• Reducing modeling error of graphical methods for estimating volume of distribution measurements in PIB-PET study
• BIOLOGICAL RECEPTORS: IMPLICATIONS OF RADIOLIGAND QUALITY IN BINDING ASSAYS
• Analysis of compartmental models of ligand-induced endocytosis
• Stochastic dynamic model for estimation of rate constants and their variances from noisy and heterogeneous PET measurements

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