On indicator dilution and perfusion heterogeneity: A stochastic model

DOI10.1016/0025-5564(87)90112-XMaRDI QIDQ1093583zbMATH OpenOpenAlexFDO

Authors Thomas A. Bronikowski, Christopher A. Dawson, John H. Linehan

Publication date 1987

Published in Mathematical Biosciences (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1016/0025-5564(87)90112-x

zbMATH Keywords

capillary transit timesconcentrationsindicator dilutionmetabolism of substratesperfusion heterogeneityperfusion kinematicsstochastic modelsubstrate indicatorunextracted vascular reference indicatorvasculary transit-time distribution

Mathematics Subject Classification ID

Medical applications (general) (92C50) Physiological, cellular and medical topics (92Cxx)

Review text

Since the concentrations of substrate indicator \(C_ S\), and an unextracted vascular reference indicator \(C_ R\), contain information about the capillary transit times of the indicator exiting the organ at a particular time, the function \(L(t)=\ln [C_ R(t)/C_ S(t)]\) is considered as the link between experimental data and the perfusion kinematics of the organ. The authors derived a formula which expresses the experimental L(t) data in terms of the mean \(\mu\) (t) and variance of the transit times of those capillaries which are contributing indicators at each sample time t, under several kinematic assumptions.

Recommendations

• Math model of the passage of a diffusible indicator throughout microcirculation based on a stochastic description of diffusion and flow
• scientific article; zbMATH DE number 1254045
• Extension of the theory of the multiple-indicator dilution technique to metabolic systems with an arbitrary number of rate constants
• Moment relations in indicator dilution theory
• A model for transit time distributions through organs that accounts for fractal heterogeneity

Cites work

• A comparative study of organ models and numerical techniques for the evaluation of capillary permeability from multiple-indicator data
• A mathematical analysis of the influence of perfusion heterogeneity on indicator extraction
• A mathematical model of indicator extraction by the pulmonary endothelium via saturation kinetics
• scientific article; zbMATH DE number 3814037 (Why is no real title available?)
• scientific article; zbMATH DE number 3305564 (Why is no real title available?)

Cited in

(7)

• Extension of the theory of the multiple-indicator dilution technique to metabolic systems with an arbitrary number of rate constants
• Heterogeneous organ models
• Moment relations in indicator dilution theory
• A model for transit time distributions through organs that accounts for fractal heterogeneity
• A stochastic model for the self-similar heterogeneity of regional organ blood flow
• scientific article; zbMATH DE number 1254045 (Why is no real title available?)
• Math model of the passage of a diffusible indicator throughout microcirculation based on a stochastic description of diffusion and flow

This page was built for publication: On indicator dilution and perfusion heterogeneity: A stochastic model

Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q1093583)