Parameter estimation in a two-compartment population pharmacokinetic model with destructive sampling

DOI10.1016/0025-5564(88)90012-0zbMath0654.92002OpenAlexW1981673960MaRDI QIDQ1108955

Richard D. McArthur

Publication date: 1988

Published in: Mathematical Biosciences (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1016/0025-5564(88)90012-0

zbMATH Keywords

pharmacokineticsmeanscovariance structurestochastic modeltwo-compartment modeldeterministic modelvariancesdestructive samplingparameter estimation methods

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) Computational methods for problems pertaining to biology (92-08) Physiological, cellular and medical topics (92Cxx)

Uses Software

• IMSL Numerical Libraries

Cites Work

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• Analysis and identification of stochastic compartment models in pharmacokinetics: Implication for cancer chemotherapy
• Pharmacokinetics with uncertainties in rate constants. III: The inverse problem
• Least Squares Estimation when the Covariance Matrix and Parameter Vector are Functionally Related
• Stochastic Models of Compartmental Systems
• A Simplex Method for Function Minimization

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