The solution used in discretizing an integral equation for studying neutrophilia

DOI10.1016/0895-7177(89)90431-7MaRDI QIDQ1115366zbMATH OpenOpenAlexFDO

Authors Blanche L. McFarland

Publication date 1989

Published in Mathematical and Computer Modelling (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1016/0895-7177(89)90431-7

zbMATH Keywords

circulating blooddistribution of sojourn time of granulocytesgranulocyte kineticsneutropenia

Mathematics Subject Classification ID

Numerical methods for integral equations (65R20) Computational methods for problems pertaining to biology (92-08) Physiological, cellular and medical topics (92Cxx)

Review text

A continuous model without feedback control was developed previously by \textit{W. M. O'Fallon}, \textit{R. I. Walker} and \textit{H. R. van der Vaart} [Acta Biother. 20, 95-124 (1971)] for granulocyte kinetics. The continuous model used the integration of a negative exponential density function to describe the behavior of the circulating blood. This study shows that when neutropenia occurs some problems are encountered, and that discretizing the integral equation is a solution around these problems.

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Cites work

• A discrete mathematical model of unlabelled granulocyte kinetics. A preliminary study of feedback control
• A mathematical model of neutrophil production and control in normal man
• A Note on the General Time-Dependent Stochastic Compartmental Model

Cited in

(1)

• A discrete mathematical model of unlabelled granulocyte kinetics. A preliminary study of feedback control

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