Estimation of the relative risk following group sequential procedure based upon the weighted log-rank statistic

DOI10.4310/SII.2014.V7.N1.A4zbMATH Open1326.62175arXiv1102.5088OpenAlexW3105961798MaRDI QIDQ117602FDOQ117602

Authors: Grant Izmirlian, Grant Izmirlian 

Publication date: 2014

Published in: Statistics and Its Interface (Search for Journal in Brave)

Abstract: In this paper we consider a group sequentially monitored trial on a survival endpoint, monitored using a weighted log-rank (WLR) statistic with deterministic weight function. We introduce a summary statistic in the form of a weighted average logged relative risk and show that if there is no sign change in the instantaneous logged relative risk, there always exists a bijection between the WLR statistic and the weighted average logged relative risk. We show that this bijection can be consistently estimated at each analysis under a suitable shape assumption, for which we have listed two possibilities. We indicate how to derive a design-adjusted p-value and confidence interval and suggest how to apply the bias-correction method. Finally, we document several decisions made in the design of the NLST interim analysis plan and in reporting its results on the primary endpoint.

Full work available at URL: https://arxiv.org/abs/1102.5088

Recommendations

• Flexibly Monitoring Group Sequential Survival Trials When Testing is Based Upon a Weighted Log-Rank Statistic
• A Group Sequential Test for Survival Trials: An Alternative to Rank‐Based Procedures
• Weighted Logrank Statistics in Sequential Tests
• Information Growth in a Family of Weighted Logrank Statistics Under Repeated Analyses
• Survivor function estimators under group sequential monitoring based on the logrank statistic

zbMATH Keywords

estimationgroup sequentialinterim analysisweighted log-rank statistic

Mathematics Subject Classification ID

Nonparametric estimation (62G05) Estimation in survival analysis and censored data (62N02) Applications of statistics to biology and medical sciences; meta analysis (62P10) Sequential estimation (62L12)

Cited In (2)

• Information Growth in a Family of Weighted Logrank Statistics Under Repeated Analyses
• PwrGSD

This page was built for publication: Estimation of the relative risk following group sequential procedure based upon the weighted log-rank statistic

Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q117602)