Fiber direction estimation, smoothing and tracking in diffusion MRI

DOI10.1214/15-AOAS880zbMATH Open1391.62257arXiv1406.0581WikidataQ33812018 ScholiaQ33812018MaRDI QIDQ125183FDOQ125183

Authors: Raymond K. W. Wong, Thomas C. M. Lee, Debashis Paul, Jie Peng, Alzheimer’S Disease Neuroimaging Initiative, Debashis Paul, Jie Peng, Raymond Wong, Thomas C. M. Lee 

Publication date: 1 September 2016

Published in: The Annals of Applied Statistics (Search for Journal in Brave)

Abstract: Diffusion magnetic resonance imaging is an imaging technology designed to probe anatomical architectures of biological samples in an in vivo and non-invasive manner through measuring water diffusion. The contribution of this paper is threefold. First it proposes a new method to identify and estimate multiple diffusion directions within a voxel through a new and identifiable parametrization of the widely used multi-tensor model. Unlike many existing methods, this method focuses on the estimation of diffusion directions rather than the diffusion tensors. Second, this paper proposes a novel direction smoothing method which greatly improves direction estimation in regions with crossing fibers. This smoothing method is shown to have excellent theoretical and empirical properties. Lastly, this paper develops a fiber tracking algorithm that can handle multiple directions within a voxel. The overall methodology is illustrated with simulated data and a data set collected for the study of Alzheimer's disease by the Alzheimer's Disease Neuroimaging Initiative (ADNI).

Full work available at URL: https://arxiv.org/abs/1406.0581

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zbMATH Keywords

Alzheimer's Disease Neuroimaging Initiative (ADNI)diffusion tensor imagingdirection smoothingfiber trackingmulti-tensor modeltractography

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) Image analysis in multivariate analysis (62H35) Biomedical imaging and signal processing (92C55)

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