Emergence of rules in cell society: Differentiation, hierarchy, and stability

DOI10.1006/BULM.1997.0034MaRDI QIDQ1289552zbMATH OpenOpenAlexWikidataFDO

Authors Chikara Furusawa, Kunihiko Kaneko

Publication date 10 April 2000

Published in Bulletin of Mathematical Biology (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/adap-org/9802002

zbMATH Keywords

differentiationhemopoietic system

Mathematics Subject Classification ID

Dynamical systems in biology (37N25) Cell biology (92C37)

Abstract: A dynamic model for cell differentiation is studied, where cells with internal chemical reaction dynamics interact with each other and replicate. It leads to spontaneous differentiation of cells and determination, as is discussed in the isologous diversification. Following features of the differentiation are obtained: (1)Hierarchical differentiation from a ``stem cell to other cell types, with the emergence of the interaction-dependent rules for differentiation; (2)Global stability of an ensemble of cells consisting of several cell types, that is sustained by the emergent, autonomous control on the rate of differentiation; (3)Existence of several cell colonies with different cell-type distributions. The results provide a novel viewpoint on the origin of complex cell society, while relevance to some biological problems, especially to the hemopoietic system, is also discussed.

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Cited in

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• Tile automaton in the well-mixed medium
• Cooperative differentiation through clustering in multicellular populations
• Regulative differentiation as bifurcation of interacting cell population
• On the strength of attractors in a high-dimensional system: Milnor attractor network, robust global attraction, and noise-induced selection.
• A cellular automata model for cell differentiation
• Robust development as a consequence of generated positional information
• Dynamical systems basis of metamorphosis: diversity and plasticity of cellular states in reaction diffusion network
• Modelling cell lineage using a meta-Boolean tree model with a relation to gene regulatory networks
• Evolution of stalk/spore ratio in a social amoeba: cell-to-cell interaction via a signaling chemical shaped by cheating risk
• Evolutionary timeline of a modeled cell
• The influence of the composition of tradeoffs on the generation of differentiated cells
• PATTERN DYNAMICS OF A MULTI-COMPONENT REACTION–DIFFUSION SYSTEM: DIFFERENTIATION OF REPLICATING SPOTS
• Selection of initial conditions for recursive production of multicellular organisms
• Coupled maps with growth and death: an approach to cell differentiation

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