Emergence of rules in cell society: Differentiation, hierarchy, and stability

DOI10.1006/BULM.1997.0034zbMATH Open0934.92010arXivadap-org/9802002OpenAlexW2161278665WikidataQ52239983 ScholiaQ52239983MaRDI QIDQ1289552FDOQ1289552

Authors: Chikara Furusawa, Kunihiko Kaneko 

Publication date: 10 April 2000

Published in: Bulletin of Mathematical Biology (Search for Journal in Brave)

Abstract: A dynamic model for cell differentiation is studied, where cells with internal chemical reaction dynamics interact with each other and replicate. It leads to spontaneous differentiation of cells and determination, as is discussed in the isologous diversification. Following features of the differentiation are obtained: (1)Hierarchical differentiation from a ``stem cell to other cell types, with the emergence of the interaction-dependent rules for differentiation; (2)Global stability of an ensemble of cells consisting of several cell types, that is sustained by the emergent, autonomous control on the rate of differentiation; (3)Existence of several cell colonies with different cell-type distributions. The results provide a novel viewpoint on the origin of complex cell society, while relevance to some biological problems, especially to the hemopoietic system, is also discussed.

Full work available at URL: https://arxiv.org/abs/adap-org/9802002

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zbMATH Keywords

differentiationhemopoietic system

Mathematics Subject Classification ID

Dynamical systems in biology (37N25) Cell biology (92C37)

Cited In (13)

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• Dynamical systems basis of metamorphosis: diversity and plasticity of cellular states in reaction diffusion network
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