Development of the T-cell repertoire: Clone size distribution

DOI10.1216/RMJM/1181072462MaRDI QIDQ1335217zbMATH OpenOpenAlexFDO

Authors Stephen J. Merrill, Alan S. Perelson, Rob J. De Boer

Publication date 27 September 1994

Published in Rocky Mountain Journal of Mathematics (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1216/rmjm/1181072462

zbMATH Keywords

antigensdistribution of clone populationsimmune responseKolmogorev forward equationsT lymphocyte repertoire

Mathematics Subject Classification ID

Applications of branching processes (60J85) Special processes (60K99) Physiology (general) (92C30) Medical applications (general) (92C50)

Recommendations

• Modeling and analysis of the meta-population dynamics of lymphocyte repertoires
• The effects of affinity mediated clonal expansion of premigrant thymocytes on the periphery T-cell repertoire
• The influence of T cell development on pathogen specificity and autoreactivity
• Cell death and the maintenance of immunological memory
• A phenomenological approach to the dynamics of activation and clonal expansion of \(T\) cells

Cites work

• A Paradoxical Instability Caused by Relatively Short-Range Inhibition
• The Classification of Birth and Death Processes
• The Differential Equations of Birth-and-Death Processes, and the Stieltjes Moment Problem

Cited in

(8)

• The effects of affinity mediated clonal expansion of premigrant thymocytes on the periphery T-cell repertoire
• Clonal exhaustion as a result of immune deviation
• Modeling and analysis of the meta-population dynamics of lymphocyte repertoires
• Feedback loops, reversals and nonlinearities in lymphocyte development
• How many TCR clonotypes does a body maintain?
• Cell death and the maintenance of immunological memory
• The influence of T cell development on pathogen specificity and autoreactivity
• The limiting conditional probability distribution in a stochastic model of T cell repertoire maintenance

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