Isologous diversification: A theory of cell differentiation
From MaRDI portal
Publication:1361455
DOI10.1007/BF02459474zbMATH Open0925.92004arXivadap-org/9606002OpenAlexW2949813468WikidataQ52286836 ScholiaQ52286836MaRDI QIDQ1361455FDOQ1361455
Authors: Kunihiko Kaneko, Tetsuya Yomo 
Publication date: 18 October 1999
Published in: Bulletin of Mathematical Biology (Search for Journal in Brave)
Abstract: Isologous diversification theory for cell differentiation is proposed, based on simulations of interacting cells with biochemical networks and cell division process following consumption of some chemicals. According to the simulations of the interaction-based dynamical systems model, the following scenario of the cell differentiation is proposed. (1) Up to some threshold number, divisions bring about almost identical cells with synchronized biochemical oscillations. (2)As the number is increased the oscillations lose the synchrony, leading to groups of cells with different phases of oscillations. (3)Amplitudes of oscillation and averaged chemical compositions start to differ by groups of cells. The differentiated behavior of states is transmitted to daughter cells. (4)Recursivity is formed so that the daughter cells keep the identical chemical character. This ``memory" is made possible through the transfer of initial conditions. (5) Successive differentiation proceeds. Mechanism of tumor cell formation, origin of stem cells, anomalous differentiation by transplantations, apoptosis and other features of cell differentiation process are also discussed, with some novel predictions. (Keywords: differentiation, chemical network, cell division, clustering, open chaos)
Full work available at URL: https://arxiv.org/abs/adap-org/9606002
Recommendations
- A theoretical approach to the large-scale evolution of multicellularity and cell differentiation
- scientific article; zbMATH DE number 3955562
- Regulative differentiation as bifurcation of interacting cell population
- A cellular automata model for cell differentiation
- Cell division, differentiation and dynamic clustering
- A structured population model of cell differentiation
- Regulation of differentiation in a population of cells interacting through a common pool
- Multi-type branching models to describe cell differentiation programs
- Understanding stem cell differentiation through self-organization theory
Cites Work
- Relevance of dynamic clustering to biological networks
- Clustering, coding, switching, hierarchical ordering, and control in a network of chaotic elements
- Globally coupled circle maps
- Homeochaos: Dynamic stability of a symbiotic network with population dynamics and evolving mutation rates
- Cell division, differentiation and dynamic clustering
- Dynamic clustering of bacterial population
- Mean field fluctuation of a network of chaotic elements. Remaining fluctuation and correlation in the large size limit
Cited In (16)
- Tile automaton in the well-mixed medium
- When does division of labor lead to increased system output?
- A nonlinear model of economic production processes
- Coupled maps with growth and death: an approach to cell differentiation
- A cellular automata model for cell differentiation
- Orthomodular lattice obtained from addressing a fixed point
- Coupled map lattices dynamics on a variable space for the study of development: A general discussion on Caenorhabditis elegans
- Robust development as a consequence of generated positional information
- Control of multistability
- Regulative differentiation as bifurcation of interacting cell population
- Evolutionary timeline of a modeled cell
- Cooperative differentiation through clustering in multicellular populations
- Selection of initial conditions for recursive production of multicellular organisms
- PATTERN DYNAMICS OF A MULTI-COMPONENT REACTION–DIFFUSION SYSTEM: DIFFERENTIATION OF REPLICATING SPOTS
- Dynamical systems basis of metamorphosis: diversity and plasticity of cellular states in reaction diffusion network
- Mathematical conditions for induced cell differentiation and trans-differentiation in adult cells
This page was built for publication: Isologous diversification: A theory of cell differentiation
Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q1361455)
