Unraveling the complexity of cell cycle effects of anticancer drugs in cell populations

DOI10.3934/DCDSB.2004.4.323zbMATH Open1044.92037OpenAlexW1972970131MaRDI QIDQ1430366FDOQ1430366

Authors Paolo Ubezio 

Publication date 27 May 2004

Published in Discrete and Continuous Dynamical Systems. Series B (Search for Journal in Brave)

Full work available at URL https://doi.org/10.3934/dcdsb.2004.4.323

zbMATH Keywords

complexityflow cytometrycell proliferationanticancer drugs

Mathematics Subject Classification ID

Medical applications (general) (92C50) Population dynamics (general) (92D25) Biophysics (92C05) Cell biology (92C37)

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• Estimation and prediction of cell cycle specific effects of anticancer drugs
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• Quantifying assays: inhibition of signalling pathways of cancer
• A theoretical analysis of interval drug dosing for cell-cycle-phase- specific drugs
• Mathematical determination of cell population doubling times for multiple cell lines
• The formation of tight tumor clusters affects the efficacy of cell cycle inhibitors: a hybrid model study

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