A backward procedure for change-point detection with applications to copy number variation detection

DOI10.48550/ARXIV.1812.10107zbMATH Open1492.62176arXiv1812.10107OpenAlexW3004546137MaRDI QIDQ147187FDOQ147187

Authors: Seung Jun Shin, Yichao Wu, Ning Hao, Seung Jun Shin, Yichao Wu, Ning Hao 

Publication date: 25 December 2018

Published in: The Canadian Journal of Statistics (Search for Journal in Brave)

Abstract: Change-point detection regains much attention recently for analyzing array or sequencing data for copy number variation (CNV) detection. In such applications, the true signals are typically very short and buried in the long data sequence, which makes it challenging to identify the variations efficiently and accurately. In this article, we propose a new change-point detection method, a backward procedure, which is not only fast and simple enough to exploit high-dimensional data but also performs very well for detecting short signals. Although motivated by CNV detection, the backward procedure is generally applicable to assorted change-point problems that arise in a variety of scientific applications. It is illustrated by both simulated and real CNV data that the backward detection has clear advantages over other competing methods especially when the true signal is short.

Full work available at URL: https://arxiv.org/abs/1812.10107

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zbMATH Keywords

copy number variationbackward detectionmean change-point modelmultiple change pointsshort signal

Mathematics Subject Classification ID

Point estimation (62F10) Applications of statistics to biology and medical sciences; meta analysis (62P10) Protein sequences, DNA sequences (92D20)

Cited In (4)

• Alternating Pruned Dynamic Programming for Multiple Epidemic Change-Point Estimation
• bwd
• Post‐selection inference for changepoint detection algorithms with application to copy number variation data
• Fast estimation of posterior probabilities in change-point analysis through a constrained hidden Markov model

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