A model for the cellular mechanisms of morphine tolerance and dependence

DOI10.1016/S0895-7177(00)00180-1MaRDI QIDQ1591880zbMATH OpenOpenAlexFDO

Authors L. O. de Azevedo, Luís Alfredo V. de Carvalho

Publication date 14 January 2001

Published in Mathematical and Computer Modelling (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1016/s0895-7177(00)00180-1

zbMATH Keywords

addictiongenetic expressionLC neuronslocus coerpuleusmolecular psychiatrymorphineopiate dependenceordinary differential equations modelprotein phosphorylationsimulationstransmembrane signalling

Mathematics Subject Classification ID

Neural biology (92C20) Medical applications (general) (92C50)

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• A theory of drug tolerance and dependence. I: A conceptual analysis
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• Modeling the onset of drug dependence: a consideration of the requirement for protein synthesis
• Mechanism of morphine addiction by inhibiting the soluble guanylate cyclase-nitric Oxide (sGC-NO) pathway

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