Hierarchical reconstructions of cardiac tissue

DOI10.1016/S0960-0779(01)00169-2MaRDI QIDQ1610091zbMATH OpenOpenAlexFDO

Authors M. J. Poole, John V. Tucker, A. V. Holden

Publication date 18 August 2002

Published in Chaos, Solitons and Fractals (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1016/s0960-0779(01)00169-2

zbMATH Keywords

biological systemcardiac tissuecomputational modelsconcurrent algorithmselectrical behaviourhierarchy

Mathematics Subject Classification ID

Qualitative investigation and simulation of ordinary differential equation models (34C60) Nonlinear parabolic equations (35K55) Physiology (general) (92C30) Medical applications (general) (92C50) Physiological, cellular and medical topics (92C99)

Review text

The contribution under review approaches a problem of extremely high interest nowadays, namely the construction of computational models of cardiac tissue. Involved here are synchronous concurrent algorithms capable of spatially modelling large biological systems, in view of a subsequent elaboration of hierarchical models. After extensive presentations (accompanied by illustrative material) of hierarchical models of the heart (and of the suggested models), viewed as algorithms, an example of SCA models of cardiac tissue is discussed in full detail. Another paragraph is dealing with the abstraction and approximation of models, again followed by convincing exemplifications; the last problem discussed is that of multilevel models. All in all, this study is recommended to all those interested in computational cardiology, but not only; biologists might find, too, extremely interesting ideas for their research.

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Cites work

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Cited in

(7)

• Unifying computers and dynamical systems using the theory of synchronous concurrent algorithms
• Reconstructing the heart
• Computable total functions on metric algebras, universal algebraic specifications and dynamical systems
• Generation of histo-anatomically representative models of the individual heart: tools and application
• AN ALGORITHMIC MODEL OF THE MAMMALIAN HEART: PROPAGATION, VULNERABILITY, RE-ENTRY AND FIBRILLATION
• An analysis of heart rhythm dynamics using a three-coupled oscillator model
• Analysis of Hopf bifurcation caused by leakage conductance \(g_{l}\) in the Hodgkin-Huxley model in muscles

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