Epidemic spreading dynamics with drug resistance and heterogeneous contacts

DOI10.1016/J.JTBI.2018.01.003zbMATH Open1397.92627arXiv1709.03818OpenAlexW2964184866WikidataQ50160578 ScholiaQ50160578MaRDI QIDQ1635541FDOQ1635541

Authors: Peng-Bi Cui, L. Gao, Wei Wang 

Publication date: 7 June 2018

Published in: Journal of Theoretical Biology (Search for Journal in Brave)

Abstract: Drug resistance and strong contacts actually play crucial roles in epidemic spread in complex systems. Nevertheless, neither theoretical model or methodology is proposed to address this. We thus consider an edge-based epidemic spread model considering the two key ingredients, in which the contacts are grouped into two classes: strong contacts and normal ones. Next, we present a unified edge-based compartmental approach to the spread dynamics on Erd"{o}s-R'{e}nyi (ER) networks and validate its results by extensive numerical simulations. In case that epidemic is totally drug-resistant, we both numerically and theoretically show a slow outbreak (continuous transition) of epidemics when number of strong contacts is not enough for the emergence of null threshold. If the epidemic owns partial resistance, we would observe evident faster-growing outbreaks (discontinuous transitions) and larger final epidemic sizes for few strong contacts, instead of emergence of null threshold with increase of strong contacts. Inhibiting effect of infection threshold, positive roles of strong contacts and strength of strong contacts in promoting outbreaks are also approved. Throughout this paper, we could drive exact predictions through the analytical approach, showing good agreements with numerical simulations.

Full work available at URL: https://arxiv.org/abs/1709.03818

Recommendations

• Dynamics of epidemic spreading model with drug-resistant variation on scale-free networks
• Epidemic spreading model of complex dynamical network with the heterogeneity of nodes
• Epidemic outbreaks on networks with effective contacts
• Mean field theory of epidemic spreading with effective contacts on networks
• Epidemic spreading on contact networks with adaptive weights

zbMATH Keywords

epidemiologydrug resistancenetwork dynamicsedge-based compartmental theory

Mathematics Subject Classification ID

Epidemiology (92D30) Applications of stochastic analysis (to PDEs, etc.) (60H30)

Cites Work

• Contact switching as a control strategy for epidemic outbreaks
• Epidemic Spread in Networks: Existing Methods and Current Challenges

This page was built for publication: Epidemic spreading dynamics with drug resistance and heterogeneous contacts

Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q1635541)