Dendritic immunotherapy improvement for an optimal control murine model

DOI10.1155/2017/5291823MaRDI QIDQ1664521zbMATH OpenOpenAlexDBLPWikidataFDO

Authors J. C. Rangel-Reyes, E. Castillo-Montiel, Juan C. Chimal-Eguía

Publication date 27 August 2018

Published in Computational \& Mathematical Methods in Medicine (Search for Journal in Brave)

Copyright license Creative Commons Attribution 4.0 International

Full work available at URL https://doi.org/10.1155/2017/5291823

zbMATH Keywords

dendritic immunotherapyoptimal control murine model

Mathematics Subject Classification ID

Applications of optimal control and differential games (49N90) Medical applications (general) (92C50)

Review text

Summary: Therapeutic protocols in immunotherapy are usually proposed following the intuition and experience of the therapist. In order to deduce such protocols mathematical modeling, optimal control and simulations are used instead of the therapist's experience. Clinical efficacy of dendritic cell (DC) vaccines to cancer treatment is still unclear, since dendritic cells face several obstacles in the host environment, such as immunosuppression and poor transference to the lymph nodes reducing the vaccine effect. In view of that, we have created a mathematical murine model to measure the effects of dendritic cell injections admitting such obstacles. In addition, the model considers a therapy given by bolus injections of small duration as opposed to a continual dose. Doses timing defines the therapeutic protocols, which in turn are improved to minimize the tumor mass by an optimal control algorithm. We intend to supplement therapist's experience and intuition in the protocol's implementation. Experimental results made on mice infected with melanoma with and without therapy agree with the model. It is shown that the dendritic cells' percentage that manages to reach the lymph nodes has a crucial impact on the therapy outcome. This suggests that efforts in finding better methods to deliver DC vaccines should be pursued.

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Cites work

• Determination of the optimal therapeutic protocols in cancer immunotherapy
• Mathematical models for immunology: current state of the art and future research directions
• Optimal control for mathematical models of cancer therapies. An application of geometric methods
• Optimal control in a model of dendritic cell transfection cancer immunotherapy
• OPTIMAL CONTROL OF MIXED IMMUNOTHERAPY AND CHEMOTHERAPY OF TUMORS

Cited in

(4)

• Optimal control in a model of dendritic cell transfection cancer immunotherapy
• Numerical solution of an optimal control model of dendritic cell treatment of a growing tumour
• A structural methodology for modeling immune-tumor interactions including pro- and anti-tumor factors for clinical applications
• A microfluidic study of mouse dendritic cell membrane transport properties of water and cryoprotectants

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