Characterization of the endemic equilibrium and response to mutant injection in a multi-strain disease model

DOI10.1016/J.JTBI.2014.12.001zbMATH Open1405.92244arXiv1404.2147OpenAlexW2149197545WikidataQ41605091 ScholiaQ41605091MaRDI QIDQ1664542FDOQ1664542

Y. Aharonov

Publication date: 27 August 2018

Published in: Journal of Theoretical Biology (Search for Journal in Brave)

Abstract: Starting from common assumptions, we build a rate equation model for multi-strain disease dynamics in terms of immune repertoire classes. We then move to a strain-level description where a low-order closure reminiscent of a pair approximation can be applied. We characterize the endemic equilibrium of the ensuing model in the absence of mutation and discuss the presence of degeneracy regarding the prevalence of the different strains. Finally we study the behavior of the system under the injection of mutant strains.

Full work available at URL: https://arxiv.org/abs/1404.2147

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zbMATH Keywords

mathematical epidemiologystrain competition and evolutionstrain cross-immunity

Mathematics Subject Classification ID

Medical epidemiology (92C60) Epidemiology (92D30)

Cites Work

• Distance spectrum of graph compositions
• Epidemiological models with age structure, proportionate mixing, and cross-immunity
• The dynamics of cocirculating influenza strains conferring partial cross-immunity
• A status-based approach to multiple strain dynamics
• Age profile of immunity to influenza: effect of original antigenic sin
• Cross-immunity, invasion and coexistence of pathogen strains in epidemiological models with one-dimensional antigenic space
• Antigenic distance and cross-immunity, invasibility and coexistence of pathogen strains in an epidemiological model with discrete antigenic space
• Characterizing the symmetric equilibrium of multi-strain host-pathogen systems in the presence of cross immunity
• When does pathogen evolution maximize the basic reproductive number in well-mixed host-pathogen systems?

Cited In (1)

• Modelling the effect of within-host dynamics on the diversity of a multi-strain pathogen

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