Characterization of the endemic equilibrium and response to mutant injection in a multi-strain disease model

DOI10.1016/J.JTBI.2014.12.001MaRDI QIDQ1664542zbMATH OpenOpenAlexWikidataFDO

Authors Y. Aharonov

Publication date 27 August 2018

Published in Journal of Theoretical Biology (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1404.2147

zbMATH Keywords

mathematical epidemiologystrain competition and evolutionstrain cross-immunity

Mathematics Subject Classification ID

Medical epidemiology (92C60) Epidemiology (92D30)

Abstract: Starting from common assumptions, we build a rate equation model for multi-strain disease dynamics in terms of immune repertoire classes. We then move to a strain-level description where a low-order closure reminiscent of a pair approximation can be applied. We characterize the endemic equilibrium of the ensuing model in the absence of mutation and discuss the presence of degeneracy regarding the prevalence of the different strains. Finally we study the behavior of the system under the injection of mutant strains.

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Cites work

• A status-based approach to multiple strain dynamics
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Cited in

(2)

• Modelling heterogeneous host immune response in a multi-strain system
• Modelling the effect of within-host dynamics on the diversity of a multi-strain pathogen

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