Analytical theory of oxygen transport in the human placenta

DOI10.1016/J.JTBI.2014.12.016MaRDI QIDQ1664571zbMATH OpenOpenAlexWikidataFDO

Authors Alexander S. Serov, Carolyn M. Salafia, M. Filoche, D. S. Grebenkov

Publication date 27 August 2018

Published in Journal of Theoretical Biology (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1406.7257

zbMATH Keywords

diffusion-convectionoptimal villi densityoxygen exchange efficiencypathology diagnosticsstream-tube placenta model

Mathematics Subject Classification ID

PDEs in connection with biology, chemistry and other natural sciences (35Q92) Physiological flows (76Z05) Physiological flow (92C35) Diffusion and convection (76R99)

Abstract: We propose an analytical approach to solving the diffusion-convection equations governing oxygen transport in the human placenta. We show that only two geometrical characteristics of a placental cross-section, villi density and the effective villi radius, are needed to predict fetal oxygen uptake. We also identify two combinations of physiological parameters that determine oxygen uptake in a given placenta: (i) the maximal oxygen inflow of a placentone if there were no tissue blocking the flow, and (ii) the ratio of transit time of maternal blood through the intervillous space to oxygen extraction time. We derive analytical formulas for fast and simple calculation of oxygen uptake and provide two diagrams of efficiency of oxygen transport in an arbitrary placental cross-section. We finally show that artificial perfusion experiments with no-hemoglobin blood tend to give a two-orders-of-magnitude underestimation of the in vivo oxygen uptake and that the optimal geometry for such setup alters significantly. The theory allows one to adjust the results of artificial placenta perfusion experiments to account for oxygen-hemoglobin dissociation. Combined with image analysis techniques, the presented model can give an easy-to-use tool for prediction of the human placenta efficiency.

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• Modeling oxygen transport in human placental terminal villi
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Cites work

• scientific article; zbMATH DE number 2194270 (Why is no real title available?)
• Modeling oxygen transport in human placental terminal villi
• Optimal villi density for maximal oxygen uptake in the human placenta
• Towards a rational modeling for the human placenta

Cited in

(7)

• Oxygen balance for small organisms: an analytical model
• A multiscale model of placental oxygen exchange: the effect of villous tree structure on exchange efficiency
• Modeling oxygen transport in human placental terminal villi
• Blood flow and transport in the human placenta
• Optimal villi density for maximal oxygen uptake in the human placenta
• Transport in the placenta: homogenizing haemodynamics in a disordered medium
• Glucose transport from mother to fetus -- a theoretical study

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