Mathematical modeling and numerical simulation of the TGF-/Smad signaling pathway in tumor microenvironments

DOI10.1016/J.APNUM.2017.11.004MaRDI QIDQ1669855zbMATH OpenOpenAlexFDO

Authors Adnan Morshed, Prashanta Dutta, Robert Dillon

Publication date 4 September 2018

Published in Applied Numerical Mathematics (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1016/j.apnum.2017.11.004

zbMATH Keywords

mathematical modelingtumor microenvironmentimmersed interface methodTGF-\(\beta\)tumorSmadTGF-\(\beta\)/Smad

Mathematics Subject Classification ID

Biochemistry, molecular biology (92C40) PDEs in connection with biology, chemistry and other natural sciences (35Q92) Cell biology (92C37)

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Cites work

• A Fast Iterative Algorithm for Elliptic Interface Problems
• A hybrid model of tumor-stromal interactions in breast cancer
• Hybrid immersed interface-immersed boundary methods for AC dielectrophoresis
• The Immersed Interface Method for Elliptic Equations with Discontinuous Coefficients and Singular Sources

Cited in

(10)

• scientific article; zbMATH DE number 7706658 (Why is no real title available?)
• Interaction of tumor with its micro-environment: a mathematical model
• Pattern formation in a nonlocal mathematical model for the multiple roles of the TGF-\(\beta\) pathway in tumour dynamics
• A mathematical model of the stoichiometric control of Smad complex formation in TGF-\(\beta\) signal transduction pathway
• Transformed epithelial cells and fibroblasts/myofibroblasts interaction in breast tumor: a mathematical model and experiments
• A dynamical model of TGF-β activation in asthmatic airways
• Spatial aspects in the SMAD signaling pathway
• Modularized smad-regulated TGF\(\beta \) signaling pathway
• Identifying therapeutic targets in a combined EGFR-TGF\(\beta\)R signalling cascade using a multiscale agent-based cancer model
• A control engineering model for resolving the TGF-\(\beta\) paradox in cancer

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