Pairwise Ising model analysis of human cortical neuron recordings

DOI10.1007/978-3-319-68445-1_30MaRDI QIDQ1689141zbMATH OpenOpenAlexFDO

Authors Trang-Anh Nghiem, Olivier Marre, Alain Destexhe, Ulisse Ferrari

Publication date 12 January 2018

Full work available at URL https://arxiv.org/abs/1710.09929

zbMATH Keywords

brain stateshuman temporal cortexIsing modelmaximum entropy principlemultielectrode array recordingnatural gradient

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) Lattice systems (Ising, dimer, Potts, etc.) and systems on graphs arising in equilibrium statistical mechanics (82B20) Neural biology (92C20)

Abstract: During wakefulness and deep sleep brain states, cortical neural networks show a different behavior, with the second characterized by transients of high network activity. To investigate their impact on neuronal behavior, we apply a pairwise Ising model analysis by inferring the maximum entropy model that reproduces single and pairwise moments of the neuron's spiking activity. In this work we first review the inference algorithm introduced in Ferrari,Phys. Rev. E (2016). We then succeed in applying the algorithm to infer the model from a large ensemble of neurons recorded by multi-electrode array in human temporal cortex. We compare the Ising model performance in capturing the statistical properties of the network activity during wakefulness and deep sleep. For the latter, the pairwise model misses relevant transients of high network activity, suggesting that additional constraints are necessary to accurately model the data.

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