Pairwise Ising model analysis of human cortical neuron recordings

DOI10.1007/978-3-319-68445-1_30zbMATH Open1426.92011arXiv1710.09929OpenAlexW3102717650MaRDI QIDQ1689141FDOQ1689141

Authors: Trang-Anh Nghiem, Olivier Marre, Alain Destexhe, Ulisse Ferrari 

Publication date: 12 January 2018

Abstract: During wakefulness and deep sleep brain states, cortical neural networks show a different behavior, with the second characterized by transients of high network activity. To investigate their impact on neuronal behavior, we apply a pairwise Ising model analysis by inferring the maximum entropy model that reproduces single and pairwise moments of the neuron's spiking activity. In this work we first review the inference algorithm introduced in Ferrari,Phys. Rev. E (2016). We then succeed in applying the algorithm to infer the model from a large ensemble of neurons recorded by multi-electrode array in human temporal cortex. We compare the Ising model performance in capturing the statistical properties of the network activity during wakefulness and deep sleep. For the latter, the pairwise model misses relevant transients of high network activity, suggesting that additional constraints are necessary to accurately model the data.

Full work available at URL: https://arxiv.org/abs/1710.09929

Recommendations

• Ising models for neural activity inferred via selective cluster expansion: structural and coding properties
• The Ising decoder: reading out the activity of large neural ensembles
• scientific article; zbMATH DE number 2226655
• The effect of nonstationarity on models inferred from neural data
• Discrete- and Continuous-Time Probabilistic Models and Algorithms for Inferring Neuronal UP and DOWN States

zbMATH Keywords

Ising modelmaximum entropy principlenatural gradientbrain stateshuman temporal cortexmultielectrode array recording

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) Neural biology (92C20) Lattice systems (Ising, dimer, Potts, etc.) and systems on graphs arising in equilibrium statistical mechanics (82B20)

Cited In (3)

• The Ising decoder: reading out the activity of large neural ensembles
• Information flow in Ising models on brain networks
• Ising models for neural activity inferred via selective cluster expansion: structural and coding properties

This page was built for publication: Pairwise Ising model analysis of human cortical neuron recordings

Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q1689141)