Semiparametric covariate-modulated local false discovery rate for genome-wide association studies

DOI10.1214/17-AOAS1077MaRDI QIDQ1697396zbMATH OpenOpenAlexFDO

Authors Rong W. Zablocki, Richard A. Levine, Andrew J. Schork, Shujing Xu, Chun C. Fan, Wesley K. Thompson, Yunpeng Wang

Publication date 19 February 2018

Published in The Annals of Applied Statistics (Search for Journal in Brave)

Full work available at URL https://projecteuclid.org/euclid.aoas/1514430285

zbMATH Keywords

Bayesian mixture modelgenome-wide association studymixture of expertsB-spline densitiesmultiple-comparison procedures

Mathematics Subject Classification ID

Bayesian inference (62F15) Applications of statistics to biology and medical sciences; meta analysis (62P10) Protein sequences, DNA sequences (92D20) Paired and multiple comparisons; multiple testing (62J15)

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Cited in

(8)

• Efficient testing and effect size estimation for set‐based genetic association inference via semiparametric multilevel mixture modeling
• Covariate-adjusted multiple testing in genome-wide association studies via factorial hidden Markov models
• Covariate-modulated large-scale multiple testing under dependence
• Covariate-adjusted precision matrix estimation with an application in genetical genomics
• Covariate Adaptive False Discovery Rate Control With Applications to Omics-Wide Multiple Testing
• Minimax powerful functional analysis of covariance tests with application to longitudinal genome‐wide association studies
• A semi-parametric Bayesian model for semi-continuous longitudinal data
• Covariate adaptive familywise error rate control for genome-wide association studies

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