A decision-theoretic comparison of treatments to resolve air leaks after lung surgery based on nonparametric modeling

DOI10.1214/16-BA1016zbMATH Open1384.62312arXiv1506.07687OpenAlexW2475792925WikidataQ41687984 ScholiaQ41687984MaRDI QIDQ1699679FDOQ1699679

Authors: Yanxun Xu, Peter F. Thall, Mehran J. Reza, P. Müller 

Publication date: 23 February 2018

Published in: Bayesian Analysis (Search for Journal in Brave)

Abstract: We propose a Bayesian nonparametric utility-based group sequential design for a randomized clinical trial to compare a gel sealant to standard care for resolving air leaks after pulmonary resection. Clinically, resolving air leaks in the days soon after surgery is highly important, since longer resolution time produces undesirable complications that require extended hospitalization. The problem of comparing treatments is complicated by the fact that the resolution time distributions are skewed and multi-modal, so using means is misleading. We address these challenges by assuming Bayesian nonparametric probability models for the resolution time distributions and basing the comparative test on weighted means. The weights are elicited as clinical utilities of the resolution times. The proposed design uses posterior expected utilities as group sequential test criteria. The procedure's frequentist properties are studied by extensive simulations.

Full work available at URL: https://arxiv.org/abs/1506.07687

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zbMATH Keywords

clinical trialutility functionBayesian nonparametricmesothelioma

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) Sequential statistical design (62L05) Sequential statistical analysis (62L10)

Cited In (4)

• Clinical trial design as a decision problem
• Dirichlet process mixtures under affine transformations of the data
• Nonparametric Bayesian inference in applications
• Title not available (Why is that?)

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