Bidirectionality from cargo thermal fluctuations in motor-mediated transport

DOI10.1016/J.JTBI.2017.04.032MaRDI QIDQ1701574zbMATH OpenOpenAlexWikidataFDO

Authors Christopher E. Miles, James P. Keener

Publication date 27 February 2018

Published in Journal of Theoretical Biology (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1605.06488

zbMATH Keywords

diffusionintracellular transportmean first passage timesmolecular motorsstochastic processes

Mathematics Subject Classification ID

Biomechanics (92C10) Cell biology (92C37)

Abstract: Molecular motor proteins serve as an essential component of intracellular transport by generating forces to haul cargoes along cytoskeletal filaments. Two species of motors that are directed oppositely (e.g. kinesin, dynein) can be attached to the same cargo, which is known to produce bidirectional net motion. Although previous work focuses on the motor number as the driving noise source for switching, we propose an alternative mechanism: cargo diffusion. A mean-field mathematical model of mechanical interactions of two populations of molecular motors with cargo thermal fluctuations (diffusion) is presented to study this phenomenon. The delayed response of a motor to fluctuations in the cargo velocity is quantified, allowing for the reduction of the full model a single "characteristic distance", a proxy for the net force on the cargo. The system is then found to be metastable, with switching exclusively due to cargo diffusion between distinct directional transport states. The time to switch between these states is then investigated using a mean first passage time analysis. The switching time is found to be non-monotonic in the drag of the cargo, providing an experimental test of the theory.

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Cites work

• A mechanism for Turing pattern formation with active and passive transport
• A quantitative examination of the role of cargo-exerted forces in axonal transport
• Asymptotic analysis of microtubule-based transport by multiple identical molecular motors
• Higher-order implicit strong numerical schemes for stochastic differential equations
• Stochastic methods. A handbook for the natural and social sciences
• Stochastic processes in cell biology

Cited in

(10)

• Motility states of molecular motors engaged in a stochastic tug-of-war
• Assessing the impact of electrostatic drag on processive molecular motor transport
• Network complexity and parametric simplicity for cargo transport by two molecular motors
• Bidirectional, unlike unidirectional transport, allows transporting axonal cargos against their concentration gradient
• Bidirectional sliding of two parallel microtubules generated by multiple identical motors
• Jump locations of jump-diffusion processes with state-dependent rates
• Effect of local dissociations in bidirectional transport of driven particles
• A semi-Markov approach to study a group of kinesin motors
• Bifurcation analysis and synapse pattern formation with bidirectional motor-mediated transports
• Model for bidirectional movement of cytoplasmic dynein

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