Matching models across abstraction levels with Gaussian processes
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Publication:1706579
DOI10.1007/978-3-319-45177-0_4zbMATH Open1382.92140arXiv1605.02190OpenAlexW2345350133MaRDI QIDQ1706579FDOQ1706579
Authors: Giulio Caravagna, Luca Bortolussi, Guido Sanguinetti 
Publication date: 22 March 2018
Abstract: Biological systems are often modelled at different levels of abstraction depending on the particular aims/resources of a study. Such different models often provide qualitatively concordant predictions over specific parametrisations, but it is generally unclear whether model predictions are quantitatively in agreement, and whether such agreement holds for different parametrisations. Here we present a generally applicable statistical machine learning methodology to automatically reconcile the predictions of different models across abstraction levels. Our approach is based on defining a correction map, a random function which modifies the output of a model in order to match the statistics of the output of a different model of the same system. We use two biological examples to give a proof-of-principle demonstration of the methodology, and discuss its advantages and potential further applications.
Full work available at URL: https://arxiv.org/abs/1605.02190
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