Modelling mass diffusion for a multi-layer sphere immersed in a semi-infinite medium: application to drug delivery
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Publication:1711947
Abstract: We present a general mechanistic model of mass diffusion for a composite sphere placed in a large ambient medium. The multi-layer problem is described by a system of diffusion equations coupled via interlayer boundary conditions such as those imposing a finite mass resistance at the external surface of the sphere. While the work is applicable to the generic problem of heat or mass transfer in a multi-layer sphere, the analysis and results are presented in the context of drug kinetics for desorbing and absorbing spherical microcapsules. We derive an analytical solution for the concentration in the sphere and in the surrounding medium that avoids any artificial truncation at a finite distance. The closed-form solution in each concentric layer is expressed in terms of a suitably-defined inverse Laplace transform that can be evaluated numerically. Concentration profiles and drug mass curves in the spherical layers and in the external environment are presented and the dependency of the solution on the mass transfer coefficient at the surface of the sphere analyzed.
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Cites work
- A semi-analytical solution for multilayer diffusion in a composite medium consisting of a large number of layers
- Critical times in multilayer diffusion. I: Exact solutions
- Handbook of linear partial differential equations for engineers and scientists
- scientific article; zbMATH DE number 3119876 (Why is no real title available?)
- scientific article; zbMATH DE number 3046362 (Why is no real title available?)
- Modelling drug-eluting stents
- Semi-analytical solution of multilayer diffusion problems with time-varying boundary conditions and general interface conditions
- Solution of multilayer diffusion problems via the Laplace transform
- Talbot quadratures and rational approximations
- The role of porous media in modeling flow and heat transfer in biological tissues.
Cited in
(8)- Generalized Laplace-type transform method for solving multilayer diffusion problems
- Drug delivery from microcapsules: how can we estimate the release time?
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- Controlled release drug delivery via polymeric microspheres: a neat application of the spherical diffusion equation
- Simplified models of diffusion in radially-symmetric geometries
- Drug delivery from polymer-based nanopharmaceuticals -- simulations of selected diffusion processes
- Random walk models of advection-diffusion in layered media
- Targeted drug delivery in multi-layer capsules: an analytical and numerical study
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