Macro scale modelling of cortical spreading depression and the role of astrocytic gap junctions

DOI10.1016/J.JTBI.2018.09.006MaRDI QIDQ1712834zbMATH OpenOpenAlexWikidataFDO

Authors Allanah Kenny, M. J. Plank, T. David

Publication date 1 February 2019

Published in Journal of Theoretical Biology (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1016/j.jtbi.2018.09.006

zbMATH Keywords

astrocytic gap junctionscomputational biologycortical spreading depressionextracellular spaceparallel computing

Mathematics Subject Classification ID

Neural biology (92C20) Physiological flow (92C35) Biochemistry, molecular biology (92C40)

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Cites work

• A mathematical model of recurrent spreading depolarizations
• Dependence of spontaneous neuronal firing and depolarisation block on astroglial membrane transport mechanisms
• Effects of glia in a triphasic continuum model of cortical spreading depression
• Models of neurovascular coupling via potassium and EET signalling
• Neurovascular coupling and the influence of luminal agonists via the endothelium
• Nucleation of reaction-diffusion waves on curved surfaces
• The role of astrocytic calcium and TRPV4 channels in neurovascular coupling
• The role of nitric oxide in neurovascular coupling

Cited in

(6)

• A computational multiscale model of cortical spreading depression propagation
• Electric potential generation of electrocytes: modelling, analysis, and computation
• The effects of cerebral curvature on cortical spreading depression
• Global sensitivity analysis of high-dimensional neuroscience models: an example of neurovascular coupling
• Role of astrocyte in cortical spreading depression: a quantitative model of neuron-astrocyte network
• Cellular communication among smooth muscle cells: the role of membrane potential via connexins

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