Learning pharmacokinetic models for in vivo glucocorticoid activation

DOI10.1016/j.jtbi.2018.07.025zbMath1406.92268OpenAlexW2883080034WikidataQ57467567 ScholiaQ57467567MaRDI QIDQ1714306

Kerstin Bunte, Peter Tiňo, Jeremy W. Tomlinson, David J. Smith, Zaki K. Hassan-Smith, Wiebke Arlt, Michael J. Chappell

Publication date: 31 January 2019

Published in: Journal of Theoretical Biology (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1016/j.jtbi.2018.07.025

zbMATH Keywords

clusteringperturbation analysispharmacokineticsdynamic systemsprobabilistic modelsexpectation maximizationidentifiability analysis11\(\beta\)-HSD activitygaussian mixture modelin vivo glucocorticoid activationpartially observed time series analysis

Mathematics Subject Classification ID

Pattern recognition, speech recognition (68T10) Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45)

Cites Work

• Self-organized formation of topologically correct feature maps
• Identifiability of uncontrolled nonlinear rational systems
• Least squares quantization in PCM
• A unified framework for approximating and clustering data
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