Standardization of multivariate Gaussian mixture models and background adjustment of PET images in brain oncology

DOI10.1214/18-AOAS1149zbMATH Open1411.62322arXiv1710.08508OpenAlexW3100896984WikidataQ128948529 ScholiaQ128948529MaRDI QIDQ1728643FDOQ1728643

Authors: Meng Li, Armin Schwartzman 

Publication date: 25 February 2019

Published in: The Annals of Applied Statistics (Search for Journal in Brave)

Abstract: In brain oncology, it is routine to evaluate the progress or remission of the disease based on the differences between a pre-treatment and a post-treatment Positron Emission Tomography (PET) scan. Background adjustment is necessary to reduce confounding by tissue-dependent changes not related to the disease. When modeling the voxel intensities for the two scans as a bivariate Gaussian mixture, background adjustment translates into standardizing the mixture at each voxel, while tumor lesions present themselves as outliers to be detected. In this paper, we address the question of how to standardize the mixture to a standard multivariate normal distribution, so that the outliers (i.e., tumor lesions) can be detected using a statistical test. We show theoretically and numerically that the tail distribution of the standardized scores is favorably close to standard normal in a wide range of scenarios while being conservative at the tails, validating voxelwise hypothesis testing based on standardized scores. To address standardization in spatially heterogeneous image data, we propose a spatial and robust multivariate expectation-maximization (EM) algorithm, where prior class membership probabilities are provided by transformation of spatial probability template maps and the estimation of the class mean and covariances are robust to outliers. Simulations in both univariate and bivariate cases suggest that standardized scores with soft assignment have tail probabilities that are either very close to or more conservative than standard normal. The proposed methods are applied to a real data set from a PET phantom experiment, yet they are generic and can be used in other contexts.

Full work available at URL: https://arxiv.org/abs/1710.08508

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zbMATH Keywords

outlier detectionspatial modelingtail distributionspositron emission tomographytumor detectionbackground adjustmentmultivariate Gaussian mixture modelPET imagesrobust EM algorithmstandardized scoresvoxelwise inference

Mathematics Subject Classification ID

Classification and discrimination; cluster analysis (statistical aspects) (62H30) Applications of statistics to biology and medical sciences; meta analysis (62P10) Image analysis in multivariate analysis (62H35)

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Cited In (2)

• Standardization of multivariate Gaussian mixture models and background adjustment of PET images in brain oncology
• Generalized Student's \(t\)-distribution mixtures for autoradiographic image spread modelling

Uses Software

• robustbase
• GSM

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