Equilibrium binding of multivalent ligands to cells: Effects of cell and receptor density

DOI10.1016/0025-5564(96)00022-3zbMATH Open0856.92006OpenAlexW1991278456WikidataQ52301341 ScholiaQ52301341MaRDI QIDQ1817441FDOQ1817441

Authors: Bernhard Sulzer, Alan S. Perelson 

Publication date: 24 February 1997

Published in: Mathematical Biosciences (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1016/0025-5564(96)00022-3

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zbMATH Keywords

B cellscell densityligand bindingaviditymultivalent ligandscell surface receptorsequilibrium binding propertieshaptenated polymersimmunon theory of B-cell activationligand depletionligand-induced cell proliferationreceptor concentration

Mathematics Subject Classification ID

Biochemistry, molecular biology (92C40) Physiology (general) (92C30) Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45) Asymptotic theory for ordinary differential equations (34E99)

Cites Work

• The kientics of bivalent ligand-bivalent receptor aggregation: Ring formation and the breakdown of the equivalent site approximation
• Receptor clustering on a cell surface. I. Theory of receptor cross- linking by ligands bearing two chemically identical functional groups
• Title not available (Why is that?)
• Receptor clustering on a cell surface. III. Theory of receptor cross- linking by multivalent ligands: Description by ligand states
• Interpretation of Scatchard plots for aggregating receptor systems

Cited In (7)

• Scaffold-mediated nucleation of protein signaling complexes: elementary principles
• Chemoreception by a cell with age-dependent receptor binding sites
• Title not available (Why is that?)
• Impact of plasma-protein binding on receptor occupancy: an analytical description
• Monotonicity of interleukin-1 receptor-ligand binding with respect to antagonist in the presence of decoy receptor
• Equilibrium competition binding assay: inhibition mechanism from a single dose response
• A model of cell surface receptor aggregation

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