Lattice gas cellular automation model for rippling and aggregation in myxobacteria

DOI10.1016/J.PHYSD.2003.11.012MaRDI QIDQ1885877zbMATH OpenOpenAlexFDO

Authors Mark Alber, Yi Jiang, Maria A. Kiskowski

Publication date 12 November 2004

Published in Physica D (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/q-bio/0401014

zbMATH Keywords

Pattern formationAggregationCellular automataStatistical mechanicsMyxobacteriaCollective behaviorRippling

Mathematics Subject Classification ID

Dynamic lattice systems (kinetic Ising, etc.) and systems on graphs in time-dependent statistical mechanics (82C20) Developmental biology, pattern formation (92C15) Cell biology (92C37) Applications of statistical mechanics to specific types of physical systems (82D99)

Abstract: A lattice-gas cellular automaton (LGCA) model is used to simulate rippling and aggregation in myxobacteria. An efficient way of representing cells of different cell size, shape and orientation is presented that may be easily extended to model later stages of fruiting body formation. This LGCA model is designed to investigate whether a refractory period, a minimum response time, a maximum oscillation period and non-linear dependence of reversals of cells on C-factor are necessary assumptions for rippling. It is shown that a refractory period of 2-3 minutes, a minimum response time of up to 1 minute and no maximum oscillation period best reproduce rippling in the experiments of {it Myxoccoccus xanthus}. Non-linear dependence of reversals on C-factor is critical at high cell density. Quantitative simulations demonstrate that the increase in wavelength of ripples when a culture is diluted with non-signaling cells can be explained entirely by the decreased density of C-signaling cells. This result further supports the hypothesis that levels of C-signaling quantitatively depend on and modulate cell density. Analysis of the interpenetrating high density waves shows the presence of a phase shift analogous to the phase shift of interpenetrating solitons. Finally, a model for swarming, aggregation and early fruiting body formation is presented.

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Cites work

• scientific article; zbMATH DE number 819507 (Why is no real title available?)
• A Stochastic Cellular Automaton Modeling Gliding and Aggregation of Myxobacteria
• Emerging patterns in a hyperbolic model for locally interacting cell systems

Cited in

(11)

• Pattern formation in an interacting cell system: rippling in myxobacterial aggregates
• Distinguishing between mechanisms of cell aggregation using pair-correlation functions
• ON MODELING COMPLEX COLLECTIVE BEHAVIOR IN MYXOBACTERIA
• Wavenumber selection in coupled transport equations
• An individual based model of rippling movement in a myxobacteria population
• Pattern formation in a reaction-advection model with delay: a continuum approach to myxobacterial rippling
• CA Models of Myxobacteria Swarming
• A new mechanism for collective migration in myxococcus Xanthus
• Extracting cellular automaton rules from physical Langevin equation models for single and collective cell migration
• Rippling of myxobacteria.
• Parameter estimation with a novel gradient-based optimization method for biological lattice-gas cellular automaton models

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