Immune response to a variable pathogen: a stochastic model with two interlocked Darwinian entities

DOI10.1155/2012/784512MaRDI QIDQ1929604zbMATH OpenOpenAlexDBLPWikidataFDO

Authors Christoph Kühn

Publication date 9 January 2013

Published in Computational \& Mathematical Methods in Medicine (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1155/2012/784512

Mathematics Subject Classification ID

Applications of branching processes (60J85) Cell biology (92C37) Medical applications (general) (92C50)

Review text

Summary: This paper presents the modeling of a host immune system, more precisely the immune effector cell and immune memory cell population, and its interaction with an invading pathogen population. It will tackle two issues of interest; on the one hand, in defining a stochastic model accounting for the inherent nature of organisms in population dynamics, namely multiplication with mutation and selection; on the other hand, in providing a description of pathogens that may vary their antigens through mutations during infection of the host. Unlike most of the literature, which models the dynamics with first-order differential equations, this paper proposes a Galton-Watson type branching process to describe stochastically by whole distributions the population dynamics of pathogens and immune cells. In the first model case, the pathogen of a given type is either eradicated or shows oscillatory chronic response. In the second model case, the pathogen shows variational behavior changing its antigen resulting in a prolonged immune reaction.

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Cited in

(7)

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• A simple model of pathogen-immune dynamics including specific and non-specific immunity

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