Addressing missing data mechanism uncertainty using multiple-model multiple imputation: application to a longitudinal clinical trial
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Publication:1940020
DOI10.1214/12-AOAS555zbMATH Open1257.62113arXiv1301.2490OpenAlexW2047802799WikidataQ30600783 ScholiaQ30600783MaRDI QIDQ1940020FDOQ1940020
Juned Siddique, Catherine M. Crespi, Ofer Harel
Publication date: 5 March 2013
Published in: The Annals of Applied Statistics (Search for Journal in Brave)
Abstract: We present a framework for generating multiple imputations for continuous data when the missing data mechanism is unknown. Imputations are generated from more than one imputation model in order to incorporate uncertainty regarding the missing data mechanism. Parameter estimates based on the different imputation models are combined using rules for nested multiple imputation. Through the use of simulation, we investigate the impact of missing data mechanism uncertainty on post-imputation inferences and show that incorporating this uncertainty can increase the coverage of parameter estimates. We apply our method to a longitudinal clinical trial of low-income women with depression where nonignorably missing data were a concern. We show that different assumptions regarding the missing data mechanism can have a substantial impact on inferences. Our method provides a simple approach for formalizing subjective notions regarding nonresponse so that they can be easily stated, communicated and compared.
Full work available at URL: https://arxiv.org/abs/1301.2490
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Cited In (11)
- Accounting for model uncertainty in multiple imputation under complex sampling
- Handling attrition in longitudinal studies: the case for refreshment samples
- A hot-deck multiple imputation procedure for gaps in longitudinal recurrent event histories
- Dual imputation model for incomplete longitudinal data
- A hot deck imputation procedure for multiply imputing nonignorable missing data: the proxy pattern-mixture hot deck
- Multiple imputation methods for handling incomplete longitudinal and clustered data where the target analysis is a linear mixed effects model
- Addressing missing data mechanism uncertainty using multiple-model multiple imputation: application to a longitudinal clinical trial
- Sequential modeling for a class of reference-based imputation methods in clinical trials with quantitative or binary outcomes
- Difference Between Binomial Proportions Using Newcombe’s Method With Multiple Imputation for Incomplete Data
- Impact of the non-distinctness and non-ignorability on the inference by multiple imputation in multivariate multilevel data: a simulation assessment
- Recent Developments in Dealing with Item Non‐response in Surveys: A Critical Review
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