A dynamic programming approach for approximate optimal control for cancer therapy

DOI10.1007/S10957-012-0137-ZMaRDI QIDQ1949602zbMATH OpenOpenAlexDBLPWikidataFDO

Authors Yanyan Li

Publication date 8 May 2013

Published in Journal of Optimization Theory and Applications (Search for Journal in Brave)

Copyright license Creative Commons Attribution 4.0 International

Full work available at URL https://doi.org/10.1007/s10957-012-0137-z

zbMATH Keywords

approximate value functioncancer therapydynamic programmingfinite horizon controlHamilton-Jacobi equationoptimal control

Mathematics Subject Classification ID

Optimality conditions for problems involving ordinary differential equations (49K15) Optimality conditions for problems involving partial differential equations (49K20) Dynamic programming in optimal control and differential games (49L20) Discrete approximations in optimal control (49M25) Applications of optimal control and differential games (49N90) Dynamic programming (90C39) Control/observation systems governed by ordinary differential equations (93C15)

Review text

A finite horizon optimal control problem arising from cancer therapy is considered. Based on the associated Hamilton-Jacobi equation, an approximate value function is introduced and a numerical scheme is developed for computing it based on some intermediate estimates.

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Cites work

• \(\varepsilon\)-value function and dynamic programming
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• Approximation of an optimal value of a Bolza functional
• Convex analysis and measurable multifunctions
• scientific article; zbMATH DE number 3505708 (Why is no real title available?)
• Optimal bang-bang controls for a two-compartment model in cancer chemotherapy
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Cited in

(7)

• Optimal syntheses for state constrained problems with application to optimization of cancer therapies
• A Fokker-Planck feedback control framework for optimal personalized therapies in colon cancer-induced angiogenesis
• Optimal control of inhibiting tumor, new approach to sufficient \(\varepsilon\)-optimality and numerical computation
• Dynamic programming approach to the numerical solution of optimal control with paradigm by a mathematical model for drug therapies of HIV/AIDS
• Dynamic programming method applied in the metabolic processes mathematic model
• An optimization technique for solving a class of nonlinear fractional optimal control problems: application in cancer treatment
• Approximate dynamic programming and its applications to the design of Phase I cancer trials

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