A comparison of a mixture likelihood method and the EM algorithm for an estimation problem in animal carcinogenicity studies

DOI10.1016/S0167-9473(99)00011-0MaRDI QIDQ1960596zbMATH OpenFDO

Authors Hojin Moon, Hongshik Ahn, Ralph L. Kodell, Bruce A. Pearce

Publication date 12 January 2000

Published in Computational Statistics and Data Analysis (Search for Journal in Brave)

zbMATH Keywords

likelihoodconstrained optimizationcause of deathcomplex methodinterval sacrifice

Mathematics Subject Classification ID

Point estimation (62F10) Nonparametric estimation (62G05) Applications of statistics to biology and medical sciences; meta analysis (62P10)

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Cites work

• scientific article; zbMATH DE number 3831154 (Why is no real title available?)
• scientific article; zbMATH DE number 3567782 (Why is no real title available?)
• A New Method of Constrained Optimization and a Comparison With Other Methods
• A Three-State Multiplicative Model for Rodent Tumorigenicity Experiments
• Analytic expressions for maximum likelihood estimators in a nonparametric model of tumor incidence and death
• Constant Risk Differences in the Analysis of Animal Tumorigenicity Data
• Nonparametric Methods for Survival/Sacrifice Experiments

Cited in

(4)

• On EM algorithms and their proximal generalizations
• A Newton-based approach for attributing tumor lethality in animal carcinogenicity studies.
• AN EXTENSION OF THE EM ALGORITHM FOR OPTIMIZATION OF CONSTRAINED LIKELIHOOD: AN APPLICATION IN TOXICOLOGY
• An EM algorithm for fitting a four-parameter logistic model to binary dose-response data

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