Bimodality in gene expression without feedback: from Gaussian white noise to log-normal coloured noise

DOI10.3934/MBE.2020361zbMATH Open1471.92123OpenAlexW3092949586WikidataQ104619352 ScholiaQ104619352MaRDI QIDQ1979564FDOQ1979564

Authors Gerardo Aquino, Andrea Rocco 

Publication date 3 September 2021

Published in Mathematical Biosciences and Engineering (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1909.03308

zbMATH Keywords

Langevin equationgene regulationnoise-induced transitionslog-normal noisewhite and coloured noise

Mathematics Subject Classification ID

Biochemistry, molecular biology (92C40) Applications of stochastic analysis (to PDEs, etc.) (60H30) White noise theory (60H40)

Abstract: Extrinsic noise-induced transitions to bimodal dynamics have been largely investigated in a variety of chemical, physical, and biological systems. In the standard approach in physical and chemical systems, the key properties that make these systems mathematically tractable are that the noise appears linearly in the dynamical equations, and it is assumed Gaussian and white. In biology, the Gaussian approximation has been successful in specific systems, but the relevant noise being usually non-Gaussian, non-white, and nonlinear poses serious limitations to its general applicability. Here we revisit the fundamental features of linear Gaussian noise, pinpoint its limitations, and review recent new approaches based on nonlinear bounded noises, which highlight novel mechanisms to account for transitions to bimodal behaviour. We do this by considering a simple but fundamental gene expression model, the repressed gene, which is characterized by linear and nonlinear dependencies on external parameters. We then review a general methodology introduced recently, so-called nonlinear noise filtering, which allows the investigation of linear, nonlinear, Gaussian and non-Gaussian noises. We also present a derivation of it, which highlights its dynamical origin. Testing the methodology on the repressed gene confirms that the emergence of noise-induced transitions appears to be strongly dependent on the type of noise adopted, and on the degree of nonlinearity present in the system.

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