Non-equilibrium statistical physics, transitory epigenetic landscapes, and cell fate decision dynamics
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Publication:1979637
Abstract: Statistical physics provides a useful perspective for the analysis of many complex systems; it allows us to relate microscopic fluctuations to macroscopic observations. Developmental biology, but also cell biology more generally, are examples where apparently robust behaviour emerges from highly complex and stochastic sub-cellular processes. Here we attempt to make connections between different theoretical perspectives to gain qualitative insights into the types of cell-fate decision making processes that are at the heart of stem cell and developmental biology. We discuss both dynamical systems as well as statistical mechanics perspectives on the classical Waddington or epigenetic landscape. We find that non-equilibrium approaches are required to overcome some of the shortcomings of classical equilibrium statistical thermodynamics or statistical mechanics in order to shed light on biological processes, which, almost by definition, are typically far from equilibrium.
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Cites work
- Bifurcations and catastrophes. Geometry of solutions to nonlinear problems. Transl. from the French by David Chillingworth
- Cellular biology in terms of stochastic nonlinear biochemical dynamics: Emergent properties, isogenetic variations and chemical system inheritability
- Conditional random matrix ensembles and the stability of dynamical systems
- Dynamical systems. Examples of complex behaviour
- scientific article; zbMATH DE number 194425 (Why is no real title available?)
- Mathematical model of adult stem cell regeneration with cross-talk between genetic and epigenetic regulation
- Non-equilibrium thermodynamics and statistical mechanics. Foundations and applications.
- Reduction of a stochastic model of gene expression: Lagrangian dynamics gives access to basins of attraction as cell types and metastabilty
- Riemannian geometry and geometric analysis
- Stability of dynamical systems
- The Morse-Witten complex via dynamical systems
- Topological sensitivity analysis for systems biology
Cited in
(6)- Transitions in the cell-fate induction induced by colored noise associated with the inductive stimulus
- The statistical physics of fixation and equilibration in individual-based models
- Identifying critical regulatory interactions in cell fate decision and transition by systematic perturbation analysis
- Mathematical modeling of heterogeneous stem cell regeneration: from cell division to Waddington's epigenetic landscape
- Towards a mathematical framework for modelling cell fate dynamics
- Dynamical theory for adaptive systems
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