Controllability of reaction systems

DOI10.1007/S41965-020-00055-XzbMATH Open1469.68039arXiv2007.09461OpenAlexW3109070087MaRDI QIDQ1982983FDOQ1982983

Authors: Sergiu Ivanov, Ion Petre 

Publication date: 14 September 2021

Published in: Journal of Membrane Computing (Search for Journal in Brave)

Abstract: Controlling a dynamical system is the ability of changing its configuration arbitrarily through a suitable choice of inputs. It is a very well studied concept in control theory, with wide ranging applications in medicine, biology, social sciences, engineering. We introduce in this article the concept of controllability of reaction systems as the ability of transitioning between any two states through a suitable choice of context sequences. We show that the problem is PSPACE-hard. We also introduce a model of oncogenic signalling based on reaction systems and use it to illustrate the intricacies of the controllability of reaction systems.

Full work available at URL: https://arxiv.org/abs/2007.09461

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zbMATH Keywords

computational complexitycontrollabilityreaction systemsoncogenic signalling

Mathematics Subject Classification ID

Systems biology, networks (92C42) Computational difficulty of problems (lower bounds, completeness, difficulty of approximation, etc.) (68Q17) Controllability (93B05) Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45) Biologically inspired models of computation (DNA computing, membrane computing, etc.) (68Q07)

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Cited In (13)

• Fixed points and attractors of reactantless and inhibitorless reaction systems
• Dynamics and control of loop reactors: a review
• Ranks of compositionally closed minimal reaction systems
• Encoding Boolean networks into reaction systems for investigating causal dependencies in gene regulation
• Numerical networks of cells
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• A P systems variant for reasoning about sequential controllability of Boolean networks
• Global controllability of chemical reactions
• Title not available (Why is that?)
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Uses Software

• WEBRSIM
• brsim

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