Coupling brain-tumor biophysical models and diffeomorphic image registration

DOI10.1016/J.CMA.2018.12.008MaRDI QIDQ1987828zbMATH OpenOpenAlexWikidataFDO

Authors Klaudius Scheufele, Andreas Mang, Amir Gholami, Christos Davatzikos, George Biros, Miriam Schulte

Publication date 16 April 2020

Published in Computer Methods in Applied Mechanics and Engineering (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1710.06420, http://europepmc.org/articles/pmc6922029

zbMATH Keywords

adjoint-based methodsatlas registrationbiophysically constrained diffeomorphic image registrationparallel algorithmstumor growth

Mathematics Subject Classification ID

Reaction-diffusion equations (35K57) Newton-type methods (49M15) Numerical optimization and variational techniques (65K10) Parallel algorithms in computer science (68W10) Biomedical imaging and signal processing (92C55) Image processing (compression, reconstruction, etc.) in information and communication theory (94A08)

Abstract: We present the SIBIA (Scalable Integrated Biophysics-based Image Analysis) framework for joint image registration and biophysical inversion and we apply it to analyse MR images of glioblastomas (primary brain tumors). In particular, we consider the following problem. Given the segmentation of a normal brain MRI and the segmentation of a cancer patient MRI, we wish to determine tumor growth parameters and a registration map so that if we "grow a tumor" (using our tumor model) in the normal segmented image and then register it to the patient segmented image, then the registration mismatch is as small as possible. We call this "the coupled problem" because it two-way couples the biophysical inversion and registration problems. In the image registration step we solve a large-deformation diffeomorphic registration problem parameterized by an Eulerian velocity field. In the biophysical inversion step we estimate parameters in a reaction-diffusion tumor growth model that is formulated as a partial differential equation. In this paper, our contributions are the introduction of a PDE-constrained optimization formulation of the coupled problem, the derivation of the optimality conditions, and the derivation of a Picard iterative scheme for the solution of the coupled problem. In addition, we perform several tests to experimentally assess the performance of our method on synthetic and clinical datasets. We demonstrate the convergence of the SIBIA optimization solver in different usage scenarios. We demonstrate that we can accurately solve the coupled problem in three dimensions ($256^3$ resolution) in a few minutes using 11 dual-x86 nodes. Also, we demonstrate that, with our coupled approach, we can successfully register normal MRI to tumor-bearing MRI while obtaining Dice coefficients that match those achieved when registering of normal-to-normal MRI.

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Cited in

(10)

• Brain–Tumor Interaction Biophysical Models for Medical Image Registration
• Where did the tumor start? An inverse solver with sparse localization for tumor growth models
• Image-Driven Biophysical Tumor Growth Model Calibration
• Analyzing the role of the inf-sup condition for parameter identification in saddle point problems with application in elasticity imaging
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• An image-driven parameter estimation problem for a reaction-diffusion glioma growth model with mass effects

Describes a project that uses

Uses Software

• TAO
• FAIR.m

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